Published in Biotech Business Week, September 15th, 2008
"However, if it is converted into either an amide, carbamate, or urea, a significant loss of potency is observed. Of the alkyl amines, small nonpolar groups are optimal for both potency and oral bioavailability," wrote Z.Q. Tian and colleagues.
The researchers concluded: "As a result of this study, one compound (KOS-2079) was taken into an animal efficacy model with success."
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