Antifungals

Research on antifungals described by Z.Q. Tian and colleagues

Published in Biotech Business Week, September 15th, 2008

"A structure-activity relationship around the amine group of the ambruticin VS series has been developed for antifungal activity. It was shown that the amine con be alkylated through reductive amination without loss of potency," researchers in the United States report.

"However, if it is converted into either an amide, carbamate, or urea, a significant loss of potency is observed. Of the alkyl amines, small nonpolar groups are optimal for both potency and oral bioavailability," wrote Z.Q. Tian and colleagues.

The researchers concluded: "As a result of this study, one compound (KOS-2079) was taken into an animal efficacy model with success."

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Source: Biotech Business Week (2008-09-15)

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