Published in Biotech Business Week, October 20th, 2008
"The optimized reaction conditions can be applied to a limited. number of other aromatic and heteroaromatic nitro compounds," wrote M. Achmatowicz and colleagues, Amgen, Inc.
The researchers concluded: "Attempts to understand the observed selectivity in the VNS step led to the discovery of two new reaction pathways under VNS conditions, one leading to an isoxazole and the other resulting in the...
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