Transplantation

Research on transplantation discussed by scientists at University of Oxford

Published in Biotech Business Week, November 24th, 2008

According to recent research from Oxford, the United Kingdom, "CD40L antibodies have proven to be powerful immunosuppressive agents in nonhuman primates but unfortunately perturb blood coagulation. Neither the therapeutic nor the prothrombotic mechanism of anti-CD40L is defined sufficiently to determine whether these effects can be uncoupled."

"Recent evidence suggests that the Fc region of anti-CD40L antibodies interacting with Fc receptors plays an important role in stabilizing platelet aggregates. An Fc-disabled, aglycosylated anti-CD40L heavy chain variant was therefore created to determine whether it might still be useful in promoting transplantation tolerance. In...

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Source: Biotech Business Week (2008-11-24)

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