Inflammation

Studies from University of Pennsylvania in the area of inflammation described

Published in Biotech Business Week, November 24th, 2008

According to a study from the United States, "Surfactant protein D (SP-D) is a member of the collectin family of soluble, innate, host defense molecules with demonstrated immunomodulatory properties in vitro. Constitutive absence of SP-D in mice is associated with lung inflammation, alteration in surfactant lipid homeostasis, and increased oxidative-nitrative stress."

"To test the hypothesis that SP-D would protect against acute lung injury from hyperoxia in vivo. Transgenic mice overexpressing rat SP-D constitutively (SP-D OE) or conditionally via regulation with doxycycline (SP-D Dox-on) were subjected to continuous hyperoxic challenge for up to 14 days. Compared with...

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Source: Biotech Business Week (2008-11-24)

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