Published in Biotech Business Week, November 24th, 2008
"We sought to determine whether other consequences of daptomycin-mediated membrane damage may contribute to cell death. Previously established assays were used to evaluate the membrane damaging activity of daptomycin at a single time-point of 10 min. More detailed time-course experiments were also performed to determine the kinetics of membrane depolarization and leakage of K+, Mg2+ and ATP. The kinetics of inhibition of...
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