Obesity

Researchers at Mayo Clinic release new data on obesity

Published in Biotech Business Week, November 24th, 2008

According to recent research from the United States, "Weight loss in response to sibutramine is highly variable. We assessed the association of specific markers of polymorphisms of candidate alpha 2A adrenoreceptor, S-HT transporter, and GN beta 3 genes and weight loss with sibutramine."

"We conducted a randomized, double-blind, pharmacogenetic study of behavioral therapy and sibutramine (10 or 15 mg daily) or placebo for 12 weeks in 181 overweight or obese participants. We measured body weight, body mass index, body composition, gastric emptying, and genetic variation (alpha 2A C1291G, 5-HTTLPR, and GN beta 3 C825T genotypes). Analysis of covariance was used to assess...

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Source: Biotech Business Week (2008-11-24)

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