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Physiology

Investigators at Thomas Jefferson University publish new data on physiology

Published in Biotech Business Week, December 15th, 2008

Fresh data on physiology are presented in the report 'Uncoupling of ER-mitochondrial calcium communication by transforming growth factor-beta.' According to a study from the United States, "Transforming growth factor-beta (TGF-beta) has been implicated as a key factor in mediating many cellular processes germane to disease pathogenesis, including diabetic vascular complications. TGF-beta alters cytosolic [Ca2+] ([Ca2+]c) signals, which in some cases may result from the downregulation of the IP3 receptor Ca2+ channels (IP3R)."

"Ca2+ released by IP3Rs is effectively transferred from endoplasmic reticulum (ER) to the mitochondria to stimulate ATP production and to allow...

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