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Physiology

Researchers at Health Science Center, Department of Pharmacology target physiology

Published in Biotech Business Week, December 15th, 2008

A new study, 'Chronic sustained and intermittent hypoxia reduce function of ATP-sensitive potassium channels in nucleus of the solitary tract,' is now available. "Activation of neuronal ATP-sensitive potassium (K(ATP)) channels is an important mechanism that protects neurons and conserves neural function during hypoxia. We investigated hypoxia (bath gassed with 95% N(2)-5% CO(2) vs. 95% O(2)-5% CO(2) in control)-induced changes in K(ATP) current in second-order neurons of peripheral chemoreceptors in the nucleus of the solitary tract (NTS)," investigators in the United States report.

"Hypoxia-induced K(ATP) currents were compared between normoxic (Norm) rats and rats...

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