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HIV/AIDS

Reports on HIV/AIDS findings from McGill University provide new insights

Published in Biotech Business Week, January 5th, 2009

Research findings, 'Delayed chain termination protects the anti-hepatitis B virus drug entecavir from excision by HIV-1 reverse transcriptase,' are discussed in a new report. According to recent research from Montreal, Canada, "Entecavir (ETV) is a potent antiviral nucleoside analogue that is used to treat hepatitis B virus (HBV) infection. Recent clinical studies have demonstrated that ETV is also active against the human immunodeficiency virus type 1 (HIV-1)."

"Unlike all approved nucleoside analogue reverse transcriptase RT) inhibitors (NRTIs), ETV contains a 3'-hydroxyl group that allows further nucleotide incorporation events to occur. Thus, the mechanism of...

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