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Life Sciences
New life sciences study findings have been reported from Wesleyan University, Department of Biology
June 1st, 2009
A new study, 'The planar cell polarity pathway directs parietal endoderm migration,' is now available. "Parietal endoderm (PE) contributes to the yolk sac and is the first migratory cell type in the mammalian embryo. We can visualize PE migration in vitro using the F9 teratocarcinoma derived embryoid body outgrowth system and, show here that PE migration is directed by the non-canonical Wnt planar cell polarity (PCP) pathway via Rho/ROCK," scientists in the United States report. "Based on golgi apparatus localization and microtubule orientation, 68.6% of cells in control outgrowths are oriented in the direction of migration. Perturbation of Wnt signaling via sFRP...
Source: Biotech Business Week (2009-06-01)
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