Published in Biotech Business Week, June 8th, 2009
"Autologous chondrocyte implantation (ACI) was established for restoring isolated structural cartilage defects in knee joints. However, results are not always convincing. Human chondrocytes from patients undergoing total knee arthroplasty were cultured in monolayer followed by condensing single chondrocytes to spheroids (chondrospheres (R)). The integrative capacity of chondrospheres was examined by implanting them into lesions in human articular cartilage...
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