Cancer

Studies from University of Paris describe new findings in cancer

Published in Biotech Business Week, July 6th, 2009

" Patients with bone metastases and elevated urinary N-telopeptide (uNTx), representing excessive bone resorption, are at increased risk for skeletal-related events (SREs), cancer progression, and death. Osteoclast-mediated bone resorption is regulated by RANKL," scientists in Villejuif, France report.

"We evaluated the effect of denosumab, a fully human monoclonal antibody against RANKL, in patients with bone metastases and elevated uNTx levels despite ongoing intravenous (IV) bisphosphonate (BP) therapy. Patients and Methods Eligible patients had histologically confirmed malignancy, >= 1 bone metastases, and uNTx levels higher than 50 nmol/L bone collagen...

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Source: Biotech Business Week (2009-07-06)

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