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Ischemia
Research results from Monash University update understanding of ischemia
July 13th, 2009
"Extracellular adenosine concentrations increase within the heart during ischemia, and any exogenous adenosine receptor agonists therefore work in the context of significant local agonist concentrations. We evaluated the interactions between A(1), A(2A), A(2B), and A(3) receptors in the presence and absence of adenosine deaminase (ADA, which is used to remove endogenous adenosine) in a cardiac cell ischemia model," scientists in Parkville, Australia report. "Simulated ischemia (SI) was induced by incubating H9c2(2-1) cells in SI medium for 12 hours in 100% N-2 gas before assessment of necrosis using propidium iodide (5 mc M) or apoptosis using AnnexinV-PE flow...
Source: Biotech Business Week (2009-07-13)
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