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Liver Failure
Studies from S.K. Acharya and colleagues reveal new findings on liver failure
July 20th, 2009
"In acute liver failure (ALF), high blood ammonia levels have been documented that correlate with mortality and complications. L-ornithine L-aspartate (LOLA) reduces ammonia levels by increasing hepatic ammonia disposal and its peripheral metabolism," scientists in New Delhi, India report. "Present study evaluated efficacy and ammonia lowering effect of LOLA in ALF. This study was placebo-controlled and blinded. We randomized 201 patients with ALF between January 2005 and October 2007 to either placebo or LOLA infusions (30 g daily) for 3 days. Arterial ammonia was measured at baseline and daily for 6 days. The primary end point was improvement in survival. The study...
Source: Biotech Business Week (2009-07-20)
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