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Ovarian Cancer
Study findings from Montreal General Hospital broaden understanding of ovarian cancer
August 3rd, 2009
According to a study from Montreal, Canada, "Loss of heterozygosity (LOH) analyses of epithelial ovarian cancers (EOCs) previously identified a candidate tumor Suppressor gene (TSG) locus Within the chromosomal region 3p25.3-pter. Loss of heterozygosity analysis was performed to define the locus and identify candidates for further study." "Loss of heterozygosity analysis of 124 malignant EOC samples of different histopathologic Subtypes using 12 polymorphic microsatellite repeat markers identified a 330-kilobase minimal region of overlapping deletions at 3p26.3 that contained contactin 4 (CNTN4) as the only known TSG candidate. However, evaluation of the LOH patterns in...
Source: Biotech Business Week (2009-08-03)
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