HIV/AIDS
Study Findings from University of Parma Broaden Understanding of HIV/AIDS
Published in Biotech Business Week, May 23rd, 2011
2011 MAY 23 -- According to recent research published in the journal Molecular Pharmaceutics, "Most active and selective strand transfer HIV-1 integrase (IN) inhibitors contain chelating functional groups that are crucial feature for the inhibition of the catalytic activities of the enzyme. In particular, diketo acids and their derivatives can coordinate one or two metal ions within the catalytic core of the enzyme."
"The present work is intended as a contribution to elucidate the mechanism of action of the HIV-IN inhibitors by studying the coordinative features of H2L1 (L-708,906), an important member of the diketo acids family of inhibitors, and...
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