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Biotech Law Weekly

Susan Hasty, Publisher

Table of Contents . . . June 4th, 2004

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Biotech Law Weekly | Other Publications

4SC AG - Agreement signed to develop compounds for autoimmune disorders

Advanced Biotherapy, Inc. - Agreement signed for humanized antibody to interferon-gamma

Cancer Treatment - Oklahoma Cancer treatment bill signed

Chimerix, Inc. - Patent granted for CMX001, an orally-active smallpox therapeutic

Correctional Health - Florida inmates detained under Jimmy Ryce Act sue over treatment

Diomed Holdings, Inc. - Device firm reports 39% increase in revenues

Drug Addiction - Prosecutor says Atlantic City can't start needle exchange program

Drug Benefits - Aetna introduces Medicare-approved drug discount card

Drug Benefits - CMS endorses discount drug card

Health Care - Pharmacy Care Alliance launches Medicare-approved drug discount card

Health Sciences Group, Inc. - U.S. patent granted for cold, flu treatment

Healthcare Access - Rite Aid to accept Medicare Approved Discount Cards

Healthcare Coverage - Medicare drug card fight obscures benefit

LAB21, Inc. - DNA testing delivers first anti-acne therapy for adults

Legal Issues - Judge grants 2-month delay on fen-phen payments

AVI BioPharma, Inc. - Pharmaceutical company reports loss of $0.21 per share

Aarhus University - Personal interviews aid study of binge drinking during pregnancy

Able Laboratories, Inc. - FDA approval granted for Theophylline tablets

Academy Medical Center, Amsterdam - Systemic treatment of esophageal cancer reviewed

Adolor Corporation - First part of NDA submitted for Entereg

Advanced Medical Optics, Inc. - Licensing agreement signed with Quest Vision

Affymax, Inc. - Biotech company expands management team

Aging - Chronic diseases of elderly women limit their locomotor and social activities

American Oriental Bioengineering, Inc. - Soybean protein peptide may inhibit growth of tumor cells

Ankara Oncology Education and Research Hospital - Radiation improves survival in node-positive breast cancer patients

AstraZeneca - Survey: Lack of public awareness about strokes related to AF

Autism Research Center, Cambridge - Too much testosterone blights social skills

Awards - Rising psychiatry researchers receive career development awards

Basel University Hospital - Intranasal influenza vaccine causes facial paralysis

Bayer Pharmaceuticals Corp. - Data: Avelox remains active against bacterial strains

Beth Israel Deaconess Medical Center, Boston - Mouse cardiac surgery techniques described

Breast Cancer - myDNA.com announces publication of breast cancer channel

CV Therapeutics, Inc. - Second phase III trial of Regadenoson initiated

Cancer Research U.K. - Over a third of parents admit sunburn slip despite warnings

Candela Corporation - Device firm reports 29% growth in revenue

Canniesburn Hospital, Glasgow - Potential for adjuvant radiotherapy doesn't sway women from reconstruction

CardioDynamics - Cardiography company acquires Medis

Cel-Sci Corp. - Agreement signed with U.S. Navy for potential malaria drug

Celgene Corp. - Study suggests investigational ADHD drug d-MPH-ER safe and effective in adults

Celgene Corporation - Focalin LA capsules improve ADHD symptoms in adult study patients

Centers for Disease Control & Prevention - Human metapneumovirus infection similar in severity to RSV in children

Centers for Disease Control & Prevention - Maternal malaria and perinatal HIV transmission interaction complicated

Central University of Venezuela - Saliva IgA levels useful for pediatric giardiasis diagnosis

Cepheid, Athens - Circumsporozoite antigens quantified in Plasmodium-infected mosquitoes

Ceregene, Inc. - Plans to further develop Alzheimer disease gene therapy confirmed

Charles University - Insulin resistance not essential component of polycystic ovary syndrome

Chi Mei Fdn. Medical Center, Tainan - Researchers describe the ultrasound features of paratesticular rhabdomyosarcoma

Chinese Academy of Medical Sciences - Telomerase activity reduced in peripheral blood mononuclear cells

Chinese University of Hong Kong - COX-2 correlates with VEGF and angiogenesis in hepatitis B-linked cancer

Chronimed, Inc. - Pharmaceutical distributor reports record revenues

Cleveland Clinic - Retroperitoneoscopic radical nephrectomy successful in super-obese

Cleveland Clinic Foundation - Geographic differences influence prostate cancer mortality rates

Columbia University - Dopamine neurons release transmitter via flickering fusion pore

Cornell University - Immune responses in patients with hepatitis C and HIV described

Crystalplex - Nanobiotech company receives $100,000 investment

Ctr. de Rech. Biomedicales des Cordeliers, Paris - Mechanism underlying MHC II loss in B-cell lymphoma identified

CuraGen Corporation - Drug developer reports $0.36 per share loss

Curative Health Services, Inc. - Infusion drug company completes acquisition of Critical Care Systems

Cytokinetics, Inc. - Small molecule drug developer prices IPO

Dartmouth College School of Medicine - UEC response to bacteria regulate immune protection in female reproductive tract

Denver Health Medical Center - Laboratory diagnosis of urinary tract infections reviewed

Digene Corporation - IARC Recognizes HPV testing as part of cervical cancer screening

Dublin City University - Tummy bug puzzle unraveled

Duke University - GW112 is a novel antiapoptotic protein

Ege University, Izmir - Porokeratosis of Mibelli can be treated effectively with cryosurgery

Eli Lilly and Co. - Alimta showed advances over Taxotere in second-line lung cancer study

Eli Lilly and Company - ADHD study patients fall asleep faster on Strattera versus methylphenidate

Emergency Contraception - Ob/gyn group issues statement on FDA's non-approval of OTC status for Plan B

EntreMed, Inc. - Phase I trial with reformulated Panzem completed

Estacio De Sa University - Fragile X syndrome premutation positively correlates with POF risk

European Institute of Oncology - Clinician diligence makes the difference in managing lymph node metastasis

Ewha Womans University - Caspase-1 mediates Fas-induced apoptosis in human astrocytoma cells

Food Safety - Two macrolide animal antibiotics pose low risk to human health, research shows

Fundacion Instituto de Inmunologia de Colombia - Displacement in 6725 SERA peptide analogue protects against malaria

Genentech, Inc. - Raman spectroscopy useful for structural analysis during formulation development

Genesis Network - Study examines preimplantation genetic diagnosis to reduce multiple births

German Cancer Research Center - Immunotherapy for cancer: Inflammations open up access to tumors

Guilford Pharmaceuticals, Inc. - Andrew R. Jordan steps down as CFO

H. Lee Moffitt Comprehensive Cancer Center - Current developments of immunotherapy in the clinic reviewed

Haemonetics Corp. - Blood-processing company reports increased revenues

Hamamatsu University - Attenuated Listeria harboring plasmids protect against tuberculosis

Harvard Medical School - Patients report high levels of trust in medical specialists

Hemosol Corp. - Biologics company announces closing of reorganization and cash infusion

Hiroshima University - Environmental estrogens direct response elements via different pathways

Horizon Medical Products, Inc. - Medical-products company reports first quarter net sales up 16%

Hospital La Pitie Salpetriere, Paris - Rosuvastatin can correct many atherogenic lipoprotein profiles

Hospital de Ninos Ricardo Gutierrez, Buenos Aires - High viral loads and diverse viremia characterize pediatric HCV infection

Houston VA Medical Center - Research differentiates fibrolamellar carcinoma from hepatocellular carcinoma

Huddinge University Hospital - Anti-obesity drug effect dependent on social status

INFOGEN, Berlin - Achieving - not merely identifying - lipid level goals is critical

INSERM EMI 0335 - Altered bone microenvironment selects for highly aggressive myeloma cells.

Imaging Diagnostic Systems, Inc. - Imaging company granted Canadian patent

Imperial College London - Simple public health measures work best in controlling outbreaks

Imperial College of London - Human T-lymphotropic virus type 1 can spread directly between lymphocytes

Inamed Corp. - Company advances botulinum toxin type A clinical development program

Indiana University - Liver transplant recipients benefit from rabbit antithymocyte therapy

Infertility - Company sponsors toll-free educational and support service for individuals

Ingelheim Pharmaceutical AG - Vestibular defects in head-tilt mice result from mutations in Nox3

International Obesity TaskForce - More than one in four English children overweight

Interpharm Holdings, Inc. - Generics company receives $21 million credit line

Invitrogen Corp. - Company provides two NIH agencies with open access to cloning technologies

Isis Pharmaceuticals, Inc. - Affinitak maker reports decrease in revenues during first quarter

Japanese National Inst. of Environmental Studies - Mice exposed to formaldehyde exhibit different inflammatory responses

Johns Hopkins University - Lysosomal tetraspanin linked to retinal degeneration in genome-wide screen

Kanagawa Children's Medical Center - New genetic mutations discovered in patients suffering from rare disorder

Keimyung University - Diagnosis of breast cancer more difficult in obese Korean women

Keio University - Interferon and sodium butyrate reduce the invasive potential of liver cancer

King Pharmaceuticals, Inc. - Pharmaceutical company reports Q1 revenue drop of 14%; withdraws 2004 guidance

Kitasato University - Rectal carcinoma cells from colitis patients have unique features

Kobe University - Stomach can be considered an endocrine organ

Kochi Medical School Hospital - Cytological and histological diagnostic markers compared

La Sapienza University - IL-15 may be beneficial for AIDS immunotherapy

Laval University - Kainic acid upregulates uncoupling protein-2 mRNA expression in brain

M.D. Anderson Cancer Center - Nonmyeloablative regimens reduce incidence of GVHD better than myeloblative

M.D. Anderson Cancer Center - PTEN transfection sensitizes prostate cancer cells to radiation therapy

Manchester Royal Infirmary - Assay to quantify antibodies to Neisseria meningitidis developed

Massachusetts Institute of Technology - Studies describe how mutations affect BRCA1 function

Max Planck Institute for Infection Biology - DNA vaccine induces protection against intracellular bacterial pathogen

McGill University, Montreal - Antisense inhibitor of methylated DNA-binding protein 2 blocks new tumors

Medco Health Solutions, Inc. - New Jersey selects Medco Medicare-approved prescription discount card

Medical College of Georgia - Mutant Stat5b defines key defective pathway in diabetic mice

Medical College of Georgia - Prevention of type 2 diabetes reviewed

Medical College of Ohio -  Moraxella catarrhalis protein is adhesin for human lung cells

Medical College of Wisconsin - Developmental pharmacology principles applied to environmental toxins

Medical University of Gdansk - Peptide MS/MS spectra evaluated with artificial neural network analysis

Medical University of Vienna - Bone marrow VEGF levels parallel the phases of chronic myeloid leukemia

Memorial Sloan-Kettering Cancer Center - New nomograms can predict survival in patients with castrate prostate cancer

Mylan Laboratories, Inc. - NDA submitted for nebivolol

Nanogen, Inc. - Patent issued for electronic devices for active biological operations

National Cardiovascular Center, Osaka - Novel transcription regulator protein p60TRP characterized

National Yang Ming University - Guillain-Barre coexists with pericarditis after influenza vaccination

Nellcor - Oklahoma Children's Hospital adopts oximetry systems

Neurogen Corp. - Drug-discovery company reports on portfolio, announces lower first quarter net losses

NeurogesX, Inc. - One-hour application of NGX-4010 patch results in sustained pain reduction

New Cross Hospital, Woverhampton - Combined image guidance can be done with reduced biopsy weights

Northwestern University - FGF2 signaling determines beta-catenin effect on neural stem cell proliferation

Novavax, Inc. - Vaccine maker reports 170% increase in total revenues during first quarter

Obihiro Univ. of Agriculture & Veterinary Medicine - Antigens of abnormal isoform of prion protein characterized

Onyx Pharmaceuticals, Inc. - Cancer-focused company reports lower first quarter net losses

Pennsylvania State University - Ambient pollutants may impair cardiac autonomic control

Penwest Pharmaceuticals Co. - Additional data needed to support Oxymorphone ER New Drug Application

Pharmaceutical Resources, Inc. - Par Pharmaceutical begins shipment of generic Glucovance tablets

Pharmessen Scientific, Inc. - Pharmaceutical company completes $300,000 equity placement

Pheromone Sciences Corp. - Healthwatchsystems acquires marketing rights to Fertilite-OV fertility monitor

Presbyterian Univ. Hospital, Pittsburgh - BK virus load correlates with clinical course of infection in renal transplants

Procter & Gamble Pharmaceuticals - Study: Testosterone patch improves desire in surgically menopausal women

Progen Industries Limited - FDA grants Orphan Drug Status to PI-88 for treatment of melanoma

Psychiatry - Majority of surveyed psychiatrists use PDAs more than four times a day

Qiagen N.V. - Netherlands holding company reports increase in first quarter net sales

Quality Assurance - Triosyn T-1000 respirator receives NIOSH certification

Queen's University Belfast - Endocrine profile normal in children with Perthes disease

RadNet Management, Inc. - MIC signs agreement with imaging provider in California

Ricardo Gutierrez Children Hospital - P6 protein intranasal vaccine protects against Haemophilus influenzae

Rigel Pharmaceuticals, Inc. - Pharmaceutical company announces first quarter 2004 financial results

Royal Free & Univ. College Medical School, London - Genetic testing for cardiovascular disease risk may not be helpful

Royal Perth Hospital - HLA-B*5701 and Hsp70-Hom M493T alleles necessary for abacavir hypersensitivity

Russian Academy of Medical Sciences - Laser destroys vascular plaques

SUNY Stony Brook - Mesenchymal stem cells make cardiac connexins and form functional gap junctions

SUNY Stony Brook - Pro-nucleotide inhibitors of adenylyl cyclases potentially therapeutic

Sangamo BioSciences, Inc. - $2M Advanced Technology Program grant awarded for ZFP TF technology research

Scripps Research Institute - Scientists publish novel findings about neovessel formation

Sepracor Inc. - Experimental drug improves sleep in older patients

Serono, Inc. - Zorbtive launched for treatment of short bowel syndrome

Sher Institutes for Reproductive Medicine - New test determines pregnancy potential of embryo before IVF implantation

Sirna Therapeutics, Inc. - Therapeutics developer closes on $18.7M private placement financing

Stanford University - Electro-osmotic flow shows promise for use in neural interfaces

Stanford University - Hematopoietic stem cells adopt mature hematopoietic fates in ischemic myocardium

State University of New York Upstate Medical Unive - Ca2+ and CaM kinase regulate neurofilament expression

State University of New York, Albany - Cyclin-dependent kinase 2 activated by cyclin E in breast cancer cells

State University of New York, Buffalo - Central obesity increases risk for elevated liver enzymes and disease

State University of New York, Buffalo - Glucose and alcohol exert different effects on reactive oxygen species

Syrrx Inc. - Grant to enable study of crystallization processes of membrane-associated proteins

Tanox, Inc. - TNX-355 phase II clinical trial initiated for treatment of HIV

Technion Israel Institute of Technology - Modification of BCR tonic signals activates receptor editing in immature B cells

Technion-Israel Institute of Technology - Protein substrates of N-terminal ubiquitination reported

Tercica, Inc. - Biopharmaceutical company reports first quarter financial results

Teva Pharmaceutical Industries - Copaxone study shows effectiveness in primary progressive MS

Tokai University - Components of acellular pertussis vaccines in Japan verified

TriPath Imaging, Inc. - Diagnostics company announces 39% increase in first quarter revenues

TriVirix Inc. - Manufacturing agreement announced for PC card blood pressure meter

Tufts Health Plan - Home monitoring program offers new support for heart failure patients

U.S. Food & Drug Administration - CpG oligodeoxynucleotides find immunotherapeutic use

U.S. National Institutes of Health - Animal studies show promise treating severe chronic pain

U.S. National Institutes of Health - Presence of certain eye disorders linked with poorer survival rates

U.S. National Institutes of Health - X-ray analysis conducted on protein vaccine candidate for malaria

U.S. Veterans Affairs Department - VA to close three hospitals

UNESP -  Bothrops jararaca venom targets tumor cells and their mediators

Univ. of California, San Diego - Questionnaire and potassium sensitivity test enable quick diagnosis

Univ. of California, San Francisco - "Cardiofunk" mutation probable source of valve problems

Univ. of California, San Francisco - The continuum of hepatitis C-related fibrosis grows with alcohol intake

Univ. of Michigan Health System - Breast exams could be 'teachable moment' to prompt colon cancer screening

Univ. of Wisconsin, Madison - Wisconsin chemists find a new chink in TB's armor

Universita Cattolica del Sacro Cuore, Rome - Deep salvage with amprenavir and lopinavir/ritonavir partially effective

Universitat de les Illes Balears - Uncoupling proteins are gender dependent and affect weight control

Universite Victor Segalen Bordeaux 2 - Translational repression mediated by the GM-CSF AU-rich element

University Children's Hospital, Brussels - Neuropeptides VIP and PACAP interact with leukemic myeloid cells

University of Alberta - Rituximab rapidly effective for patients with cold and warm autoantibodies

University of Bari - Early HITT diagnosis crucial for Lepirudin efficacy

University of Bologna - Hamster model for Chlamydia pneumoniae infection developed

University of California - Urban homeless often battle chronic lung disease

University of California, Davis - Isoflavone compound may benefit men

University of Cambridge - Chemokines and cytokines expressed in Salmonella-infected chicken hatchlings

University of Cambridge - Murine herpesvirus-68 ORF73 critical for latency establishment and maintenance

University of Frankfurt - Valproic acid modulates the synthesis of angiogenic proteins in cancer cells

University of Fribourg - In vivo gene delivery with regulatable lentivirus surveys neurogenic function

University of Goteborg - Staphylococcal protease does not affect outcome of infectious arthritis

University of Heidelberg - Gefitinib and trastuzumab show promise for treatment of metastatic breast cancer

University of Helsinki - Effects of imipramine on prefrontal cortex gene expression elucidated

University of Illinois -  T. brucei genes encode functional PMCAs essential for Ca2+ homeostasis

University of Illinois - Role of conserved acidic residue in LDL-A determined

University of London - Novel C. rodentium type III secreted proteins reduce colon hyperplasia

University of Manchester - Direct cell contact influences fate of bone marrow mesenchymal stem cells

University of Maryland - Fes regulates myeloid differentiation via transcription factors

University of Massachusetts - Thymic Notch1 activation regulated by p53

University of Miami - Some melanoma cells use the abluminal surface of vessels for migration

University of Michigan - Regulation of luteinizing hormone receptor expression reviewed

University of Naples - Cognitive impairment is common in older patients with congestive heart failure

University of Nebraska - Aromatase inhibitors for postmenopausal breast cancer therapy reviewed

University of North Carolina - Study may help predict premature infants at risk of total blindness

University of Oxford - MRI represents food texture and oral fat in the human brain

University of Oxford - Response to conserved epitope linked to protection from malaria

University of Paris 11 - Hepatocellular carcinomas present newly identified characteristics

University of Pittsburgh - Prostate-specific antigen doubling time is useful in finding recurrent disease

University of S. Florida - A heme oxygenase-1 plasmid system protects the heart from ischemic injury

University of Uppsala - Oral diphtheria vaccine with microparticle adjuvant is immunogenic

University of Warwick - Fat-fighting undermined by over active eating pacemaker

University of York - E-Health is no threat to GPs

University of the West of England - Nociceptin/orphanin FQ modulates T-cell activity

Vicuron Pharmaceutical - Novel inhibitors of bacterial RNA polymerase I characterized

Virginia Polytechnic Institute - Weight loss is critical to effective management of obesity hypertension

ViroLogic, Inc. - Biotechnology company reports 29% increase in first quarter revenue

Wageningen University - Leptin responsiveness not affected by variation in leptin receptor gene

Wake Forest University - Monkey study suggests ET may lower androgens in postmenopausal women

Warsaw School of Medicine - Serum growth factor activity characterized in hemodialysis patients

Yale University - Ethanol post-fixation enhances histological bone analyses

Yale University - Losing a job near retirement age significantly increases risk of stroke

Yale University - Night-time eating in adults with binge eating disorder described

Yamaguchi University School of Medicine - Future savings offset the initial costs of treating chronic hepatitis C

Zambon Group - Newron inks agreement to develop novel treatments for pain conditions

iCAD, Inc. - CAD products manufacturer reports 145% increase in first quarter sales

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