University of Wroclaw
Dimerization of HLA-DR peptide fragment enhances immunosuppression
Published in Biotech Law Weekly, June 18th, 2004
Previous studies "revealed that the nonapeptide fragment of HLA-DR molecule, located in the beta chain 164-172 with the VPRSGEVYT sequence, suppresses the immune responses," scientists in Poland explained. "The sequence is located on the exposed molecule loop, therefore it may be involved in the interactions with other proteins."
"We suggested that the loop may serve as a functional epitope on the HLA class II surface for intermolecular binding, and that possible mechanism of biological action of the synthesized peptides is associated with interfering of...
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Source: Biotech Law Weekly (2004-06-18)
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