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Slovak Academy of Sciences

DNA double-strand break repaired by homologous recombination

Published in Biotech Law Weekly, July 2nd, 2004

DNA double-strand breaks are repaired by homologous recombination.

According to recent research from Slovakia, "DNA double-strand breaks (DSB) are presumed to be the most deleterious DNA lesions as they disrupt both DNA strands. Homologous recombination (HR), single-strand annealing, and non-homologous end-joining are considered to be the pathways for repairing DSB."

"In this review, we focus on DSB repair by HR," said Andrej Dudas and Miroslav Chovanec at the Slovak Academy of Sciences. "The proteins involved in this process as well as the interactions among them are summarized and characterized. The main emphasis is on eukaryotic cells,...

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