University of Pittsburgh
DC maturation by AdV transduction enhances tumor Ag-specific T cell response
Published in Biotech Law Weekly, July 23rd, 2004
According to a study from the United States, "Dendritic cells (DCs) have been shown to require a degree of maturation to stimulate antigen-specific, type I cytotoxic T lymphocytes in numerous murine models. Limited data in humans suggest that immature DCs (DC) can induce tolerance, yet a variety of nonmatured DC used clinically have induced antigen-specific type I T cells in vivo to various tumor-associated antigens."
"Use of adenovirus to engineer DCs is an efficient method for delivery of entire genes to DC," L. Schumacher and colleagues reported,...
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Source: Biotech Law Weekly (2004-07-23)
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