Japan National Institute of Genetics, Mishima
hesr2 activity may be important for proper development of cardiomyocytes
Published in Biotech Law Weekly, November 19th, 2004
According to recent research published in the journal Circulation Research, "Genes involved in the Notch signaling pathway have been shown to be critical regulators of cardiovascular development. In vitro studies have revealed that the Notch signaling pathway directly regulates transcription of hairy and enhancer of split-related (hesr) genes, encoding basic helix-loop-helix transcription factors. To assess the functional role of hesr genes in cardiovascular development, we generated mice with a targeted disruption of the hesr2 gene and...
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Source: Biotech Law Weekly (2004-11-19)
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