JJ Pharma Inc.
Carbohydrate-geldanamycin conjugates synthesized into potent anticancer drug
Published in Biotech Law Weekly, April 8th, 2005
According to recent research from the United States, "Geldanamycin (GA) is a potent anticancer antibiotic that inhibits Hsp-90. Its potential clinical utility is hampered by its severe toxicity. To alleviate this problem, we synthesized a series of carbohydrate-geldanamycin conjugates for enzyine-specific activation to increase tumor selectivity."
"The conjugation was carried out at the C-17-position of GA. Their anticancer activity was tested in a number of cancer cell lines. The enzyme-specific activation of...
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Source: Biotech Law Weekly (2005-04-08)
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