University College London

Prion protein analyzed, expression in the megakaryocyte lineage determined

Published in Biotech Law Weekly, August 5th, 2005

Research published from England has documented the expression of prion protein (PrP^C) in the megakaryocyte lineage

"Cellular PrP^C) is a naturally occurring protein in normal individuals which adopts an abnormal conformation, termed scrapie prion protein (PrP^Sc) that is associated with disease. There is great concern that clinically asymptomatic variant Creutzfeldt-Jacob disease (vCJD) may transmit PrP^Sc in blood transfusion products," wrote R. Starke and colleagues, University College London.

"PrP^C is widely expressed and has been found in human blood. The majority of cellular borne...

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Source: Biotech Law Weekly (2005-08-05)

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