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Oita University

Interleukin-12 immunotherapy hastens the demise of solid tumors

Published in Biotech Law Weekly, August 26th, 2005

Interleukin-12 immunotherapy hastens the demise of solid tumors.

"A conventional dendritic cell (DC)-based immunotherapy has been tested clinically for treatment of patients with advanced cancer but requires modification to further improve the clinical results. In this study, we evaluated the in vivo antitumor effects of DC therapy, non-viral-mediated interleukin (IL)-12 gene therapy, and a combination of the two in a murine bilateral subcutaneous tumor model," scientists in Japan report.

"DC therapy alone and IL-12 gene therapy alone suppressed tumor growth at the injected sites. However, the antitumor effect on the distant contralateral tumor was...

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