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Academy of Sciences of the Czech Republic, Libechov
Antimitotic and anticancer activities may be associated with epigenetic regulation
November 4th, 2005
Cyclin-dependent kinase inhibition results in downregulation of three histone variants, indicating that antimitotic and anticancer activities may be associated with epigenetic regulation. According to a study from Czech Republic, "The purpose of this study was to apply a recently introduced proteomic based approach to identify candidate biomarkers of the response to anticancer activity of cyclin-dependent kinase inhibitor, bohemine. Mapping of the total protein expression of CEM lymphoblastic leukemia cells following bohemine treatment was performed by 2-D liquid phase separation." "Proteins were fractionated by isoelectric points in pH gradient in...
Source: Biotech Law Weekly (2005-11-04)
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