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Case Western Reserve University, Cleveland

Anti-inflammatory therapies are good weapons in the fight against AD

In a recent issue of the Journal of Neuroscience, J. Koenigsknecht-Talboo and associates at Case Western Reserve University, Cleveland, "Microglia undergo a phenotypic activation in response to fibrillar beta-amyloid (fA beta) deposition in the brains of Alzheimer's disease (AD) patients, resulting in their elaboration of inflammatory molecules. Despite the presence of abundant plaque-associated microglia in the brains of AD patients and in animal models of the disease, microglia fail to efficiently clear fA beta deposits. However, they can be induced to do so during A...

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