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Charles University, Prague
Influence of esterification and modification of A-ring studied
November 4th, 2005
Scientists studied the influence of esterification and modification of A-ring in a group of lupane acids on their cytotoxicity. According to recent research from Czech Republic, "The aim of this work was to find an optimal ester group for preparation of lupane derivatives connecting high cytotoxicity with good chemical and pharmacological properties." "Activities of methyl-, pivaloyloxymethyl-(Pom-), and acetoxymethyl(Acm-) esters were compared with the activity of free acids. Although the methyl- and Pom-esters were generally less active than free acids, some Acm-esters had cytotoxicity similar to or even better than the starting compounds,"...
Source: Biotech Law Weekly (2005-11-04)
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