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Catholic University of Leuven

 Xenopus tadpoles model the underpinnings of lymphangiogenesis

"Lymph vessels control fluid homeostasis, immunity and metastasis. Unraveling the molecular basis of lymphangiogenesis has been hampered by the lack of a small animal model that can be genetically manipulated," investigators in Belgium report.

"Here, we show that Xenopus tadpoles develop lymph vessels from lymphangioblasts or, through transdifferentiation, from venous endothelial cells. Lymphangiography showed that these lymph vessels drain lymph, through the lymph heart, to the venous circulation," wrote A. Ny and colleagues, Catholic University of Leuven.

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