Tokyo Medical & Dental University

Nucleotide variations in SERPINB genes are associated with prostate cancer

Published in Biotech Law Weekly, January 13th, 2006

Nucleotide variations in the serine proteinase inhibitor B family (SERPINB) of genes were associated with prostate cancer.

According to recent research from Japan, "Genes encoding the SERPINB are mainly clustered on human chromosome 18 (18q21). Several serpins are known to affect malignant phenotypes of tumor cells, so aberrant genetic variants in this molecular family are candidates for conferring susceptibility for risk of cancer."

"We investigated whether 8 selected non-synonymous variations within SERPINB loci at 18q21 might be associated with risk of prostate cancer in Japanese men. A case-control study involving 292 prostate-cancer patients and...

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Source: Biotech Law Weekly (2006-01-13)

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