National Yang Ming University, Taipei

Oxidized LDL exposure enhances TNF-alpha-stimulated endothelial adhesiveness of monocytes

Published in Biotech Law Weekly, May 26th, 2006

Long-term exposure to oxidized low-density lipoprotein (LDL) enhances tumor necrosis factor(TNF)-alpha-stimulated endothelial adhesiveness of monocytes by activating superoxide generation and redox-sensitive pathways.

According to a report from Taiwan, "This study was conducted to investigate the role of oxidized low-density lipoprotein (LDL) in monocyte/mononuclear cell (MNC) activation during atherogenesis. First, the activity of MNCs was studied in patients with coronary artery disease (CAD)."

J.W. Chen and colleagues at National Yang-Ming University explained, "Compared to normal subjects, phorbol 12-myristate 13-acetate (PMA)-stimulated reactive...

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Source: Biotech Law Weekly (2006-05-26)

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