University of Chicago, U.S.

Grape seed proanthocyanidin-induced cytotoxicity linked to excessive NO production

Published in Biotech Law Weekly, July 7th, 2006

Endogenous NO synthase (NOS) activation and excessive NO production play a key role in the pathogenesis of high-dose grape seed proanthocyanidin extract-induced cytotoxicity.

Scientists writing in the journal Cell Biology and Toxicology report, "Grape seed proanthocyanidin extract (GPSE) at high doses has been shown to exhibit cytotoxicity that is associated with increased apoptotic cell death. Nitric oxide (NO), being a regulator of apoptosis, can be increased in production by the administration of GSPE."

"In a chick cardiomyocyte study," wrote Z.H. Shao and colleagues at University of Chicago, "we demonstrated that high-dose (500 mcg/ml)...

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Source: Biotech Law Weekly (2006-07-07)

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