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Seattle Genetics

Seattle Genetics reaches milestone in antibody-drug conjugate collaboration with CuraGen

Published in Biotech Law Weekly, July 21st, 2006

Seattle Genetics, Inc. (SGEN) announced that it has achieved a milestone under its antibody-drug conjugate (ADC) collaboration agreement with CuraGen Corporation (CRGN), triggering an undisclosed payment to Seattle Genetics.

The milestone was achieved upon CuraGen's initiation of a phase 1 clinical trial with its lead ADC, CR011-vcMMAE, for the treatment of metastatic melanoma.

ADCs utilize the targeting ability of monoclonal antibodies to deliver cell-killing payloads to tumor cells. Seattle Genetics' ADC technology employs synthetic, highly potent drugs, such as monomethyl auristatin E (MMAE), which are attached to antibodies through proprietary...

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