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University of Alberta, Canada

Reports from Canada, Australia and the United Kingdom advance knowledge in transplants research

Published in Biotech Law Weekly, July 28th, 2006

Reports from Canada, Australia and the United Kingdom highlight recent research in transplants.

Study 1: Research from Canada has reported on the detection of changes in the transcriptome in allograft rejection.

"We used Affymetrix Microarrays to define interferon-gamma (IFN-gamma)-dependent, rejection-induced transcripts (GRITs) in mouse kidney allografts. The algorithm included inducibility by recombinant IFN-gamma in kidneys of three normal mouse strains, increase in kidney allografts in three strain combinations and less induction in IFN-gamma-deficient allografts," wrote K.S. Famulski and colleagues, University of Alberta.

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