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Catholic University of Louvain, Belgium
Adiponectin downregulates its own production and the expression of its receptor
August 18th, 2006
According to recently published research from Belgium, adiponectin (ApN) downregulates its own production and the expression of its AdipoR2 receptor in transgenic mice. "ApN is an adipokine whose expression and plasma levels are inversely related to obesity and insulin-resistant states. The in vivo effects of a chronic expression of exogenous ApN restricted to adipose tissue are unclear. "Moreover, the regulatory effects of ApN on its own expression and on that of its receptors are still unknown. In this study, we generated transgenic (Tg) mice with moderate expression of exogenous ApN targeted to adipose tissue (native full-length ApN being placed...
Source: Biotech Law Weekly (2006-08-18)
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