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Australian National University, Australia
Immunity against secondary poxvirus infection depends on antibody, not on CD4 or CD8 function
August 18th, 2006
Protective immunity against secondary poxvirus infection is dependent on antibody but not on CD4 or CD8 T-cell function. According to a report from Australia, "Renewed interest in smallpox and the need for safer vaccines have highlighted our lack of understanding of the requirements for protective immunity. Since smallpox has been eradicated, surrogate animal models of closely related orthopoxviruses, such as ectromelia virus, have been used to establish critical roles for CD8 T cells in the control of primary infection." "To study the requirements for protection against secondary infection, we have used a prime-challenge regime, in which avirulent...
Source: Biotech Law Weekly (2006-08-18)
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