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Case Western Reserve University, U.S.
Antiangiogenic polypeptide relies on permissive matrix proteins to generate apoptosis
August 18th, 2006
Antiangiogenic polypeptide relies on permissive matrix proteins to generate apoptosis. "High-molecular-weight kininogen (HK) is an abundant plasma protein that plays a central role in activation of the kallikrein-kinin system. Cleavage of HK by plasma kallikrein results in release of the nonapeptide bradykinin (BK), leaving behind cleaved high-molecular-weight kininogen (HKa)," investigators in the United States report. "Previous studies have demonstrated that HKa induces apoptosis of proliferating endothelial cells and inhibits angiogenesis in vivo, activities mediated primarily through its domain 5. However, the mechanisms by which these effects...
Source: Biotech Law Weekly (2006-08-18)
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