Oncology

Solid tumors respond to heparanase inhibitor PI-88

Published in Biotech Law Weekly, November 17th, 2006

Solid tumors responded to heparanase inhibitor PI-88.

"PI-88 is a mixture of highly sulfated oligosaccharides that inhibits heparanase, an extracellular matrix endoglycosidase, and the binding of angiogenic growth factors to heparan sulfate. This agent showed potent inhibition of placental blood vessel angiogenesis as well as growth inhibition in multiple xenograft models, thus forming the basis for this study," investigators in the United States reported.

"This study evaluated the toxicity and pharmacokinetics of PI-88 (80-315 mg) when administered s.c. daily for 4 consecutive days bimonthly (part 1) or weekly (part 2). Forty-two patients [median...

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Source: Biotech Law Weekly (2006-11-17)

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