Diabetes Pathogenesis

In diabetic model, hyperphagia is linked to leptin resistance and NPY mRNA in arcuate nucleus

Published in Biotech Law Weekly, November 17th, 2006

In a diabetic rat model, hyperphagia is association with leptin resistance and increased neuropeptide Y mRNA in the arcuate nucleus.

According to recent research published in the Journal of Neuroendocrinology, "The present study aimed to examine whether hyperphagia, which is frequently observed in type 1 diabetic patients and model animals, also occurs in type 2 diabetic Goto-Kakizaki (GK) rats and, if so, to explore underlying abnormalities in the hypothalamus."

F. Maekawa and colleagues working with the Jichi Medical University explained, GK rats at postnatal weeks 6-12, compared to control Wistar rats, exhibited hyperphagia, hyperglycaemia,...

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Source: Biotech Law Weekly (2006-11-17)

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