Reports from University of Nijmegen, Department of Clinical Chemistry describe recent advances in proteomics

Data detailed in "Feature-based reappraisal of the Bacillus subtilis exoproteome" have been presented. "Proteomics-based verification of computer-assisted predictions on bacterial protein export have indicated that problems occur with the distinction between (Sec-type) signal peptides that govern protein secretion, and lipoprotein signal peptides or amino-terminal membrane anchors that cause protein retention in the membrane. Therefore, the main aim of this study was to investigate whether feature-based predictions by the SecretomeP (SecP) algorithm will aid the proteomics-based analysis of protein export in Bacillus subtilis," investigators in Nijmegen, Netherlands report.

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