Pharmacokinetics
Research on pharmacokinetics discussed by scientists at Walter Reed Army Institute of Research, Division of Experimental Therapeutics
Published in Biotech Law Weekly, August 31st, 2007
New investigation results, "Pharmacokinetics, safety, and hydrolysis of oral pyrroloquinazolinediamines administered in single and multiple doses in rats," are detailed in a study published in Antimicrobial Agents and Chemotherapy. According to recent research published in the journal Antimicrobial Agents and Chemotherapy, "Pyrroloquinazolinediamine (PQD) derivatives such as tetra-acetamide PQD (PQD-A4) and bis-ethylcarbamyl PQD (PQD-BE) were much safer (with therapeutic indices of 80 and 32, respectively) than their parent compound, PQD (therapeutic index, 10). Further evaluation of PQD-A4 and PQD-BE in single and multiple pharmacokinetic (PK) studies as well as...
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Source: Biotech Law Weekly (2007-08-31)
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