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Copernicus Therapeutics
Sustained release of DNA achieved with lipid microtubules and agarose hydrogel
May 14th, 2003
The sustained release of DNA was achieved with lipid microtubules and agarose hydrogel. "Non-viral gene therapy typically results in low transfection efficiencies and transient gene expression. To address these limitations, two sustained delivery systems capable of releasing functional, compacted DNA for over 50 days were designed," investigators in the United States report. "A luciferase plasmid was compacted with a polylysine-polyethylene glycol conjugate and released from agarose hydrogel and lipid microtubule-hydrogel delivery systems for over 50 days," said Nancy J. Meilander and collaborators at Case Western Reserve University and Copernicus...
Source: Biotech Week (2003-05-14)
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