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Academy Sinica
Breast cancer may be initiated by estrogen exposure, which causes DNA DSBs
July 30th, 2003
Breast cancer may be initiated by estrogen exposure, which causes DNA DSBs. "The role of the familial breast cancer susceptibility genes, BRCA1 and BRCA2, in the homologous recombination pathway for DNA double-strand break (DSB) repair suggests that the mechanisms involved in DNA DSB repair are of particular etiological importance during breast tumorigenesis," scientists writing in the journal Cancer Research report. "However, there is currently no evidence for an association between breast cancer and the other DSB repair pathway, the nonhomologous end-joining (NHEJ) pathway. It is possible that, because this DNA repair pathway is so crucial...
Source: Biotech Week (2003-07-30)
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