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AntiCancer, Inc.
Methioninase gene therapy causes apoptosis in bcl-2-expressing lung cancers
July 30th, 2003
Methioninase gene therapy causes apoptosis in bcl-2-expressing lung cancers. "We have previously shown that the toxic pro-oxidant methylselenol is released from selenomethionine (SeMET) by cancer cells transformed with the adenoviral methionine alpha, gamma-lyase (methioninase, MET) gene cloned from Pseudomonas putida. Methylselenol damaged the mitochondria via oxidative stress, and caused cytochrome c release into the cytosol, thereby activating caspase enzymes and thereby apoptosis. However, gene therapy strategies are less effective if tumor cells overexpress the antiapoptotic mitochondrial protein bcl-2," according to researchers in the United States. ...
Source: Biotech Week (2003-07-30)
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