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Bates College
Ubiquitin systems tilt toward recognition of hepatitis A virus 3D polymerase
July 30th, 2003
Ubiquitin systems tilt toward recognition of hepatitis A virus 3D polymerase. According to a study from the United States, "the hepatitis A virus 3C protease and 3D RNA polymerase are present in low concentrations in infected cells. The 3C protease was previously shown to be rapidly degraded by the ubiquitin/26S proteasome system and we present evidence here that the 3D polymerase is also subject to ubiquitination-mediated proteolysis." "Our results show that the sequence (32)LGVKDDWLLV(41) in the 3C protease serves as a protein destruction signal recognized by the ubiquitin-protein ligase E3alpha and that the destruction signal for the RNA...
Source: Biotech Week (2003-07-30)
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