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Brigham & Women's Hospital
Autoimmune optic neuritis may target myelin oligodendrocyte glycoprotein
July 30th, 2003
Optic neuritis in multiple sclerosis may develop due to involvement of myelin oligodendrocyte glycoprotein as a possible target antigen. "Multiple sclerosis (MS) is considered to be an autoimmune disease of the central nervous system (CNS) that in many patients first presents clinically as optic neuritis. The relationship of optic neuritis to MS is not well understood. We have generated novel T cell receptor (TCR) transgenic mice specific for myelin oligodendrocyte glycoprotein (MOG)," scientists writing in the Journal of Experimental Medicine report. "MOG-specific transgenic T cells are not deleted nor tolerized and are functionally...
Source: Biotech Week (2003-07-30)
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