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The mu opioid receptor has strong anti-inflammatory control in colitis models
July 30th, 2003
The mu opioid receptor has strong anti-inflammatory control in colitis models; MOR agonists may thus be beneficial. According to recent research published in the Journal of Clinical Investigation, "The physiologic role of the mu opioid receptor (MOR) in gut nociception, motility, and secretion is well established. "To evaluate whether MOR may also be involved in controlling gut inflammation, we first showed that subcutaneous administration of selective peripheral MOR agonists, named DALDA and DAMGO, significantly reduces inflammation in 2 experimental models of colitis induced by administration of 2,4,6-trinitrobenzene sulfonic acid (TNBS) or...
Source: Biotech Week (2003-07-30)
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