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Catholic University

Lipid and protein oxidation promote prothrombotic state in diabetic patients

"Diabetes mellitus (DM) is associated with enhanced lipid oxidation and persistent platelet activation. We investigated whether oxidant stress (OS) also affects circulating proteins and is associated with an abnormal coagulative pattern," investigators in Italy report.

"In 72 type 2 DM (T2DM) patients, urinary 8-iso-prostaglandin (PG) F_2alpha and 11-dehydro-thromboxane B₂ (TXM) were measured as markers of lipid peroxidation and platelet activation, respectively," said Raimondo De Cristofaro and colleagues at Catholic University...

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