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Catholic University, Louvain
SOX18 transcription factor is fundamental to blood and lymph vessel development
July 30th, 2003
SOX18 transcription factor is fundamental to blood and lymph vessel development. "Hereditary lymphedema is a developmental disorder characterized by chronic swelling of the extremities due to dysfunction of the lymphatic vessels. Two responsible genes have been identified: the vascular endothelial growth factor receptor 3 (VEGFR3) gene, implicated in congenital lymphedema, or Milroy disease, and the forkhead-related transcription factor gene FOXC2, causing lymphedema-distichiasis. We describe three families with an unusual association of hypotrichosis, lymphedema, and telangiectasia," scientists in Belgium report. "Using microsatellite analysis, we...
Source: Biotech Week (2003-07-30)
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