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Aarhus University
Hydrodynamic human growth hormone gene transfer normalizes murine growth
September 10th, 2003
Hydrodynamic human growth hormone gene transfer normalizes murine growth. According to a study from Denmark, "nonviral gene transfer was investigated as a potential treatment of growth hormone deficiency (GHD) using hypophysectomized mice as a model." "After a single hydrodynamic administration of naked plasmid DNA containing the human growth hormone (hGH) gene controlled by an ubiquitin promoter, sustained elevation of circulating hGH was observed the entire observation period (68 days), with a concomitant normalization of circulating insulin-like growth factor I (IGF-I) and IGF-binding protein-3. Furthermore, longitudinal growth was corrected in...
Source: Biotech Week (2003-09-10)
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