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Biogen, Inc.
Researchers decrypt the role of Cripto in tumor growth
September 10th, 2003
The cell-surface-associated molecule Cripto is overexpressed in a wide range of epithelial cancers, yet little is known about the potential mechanisms by which Cripto expression might enhance tumor growth. A new study by Michele Sanicola and colleagues at Biogen, Inc. in the Journal of Clinical Investigation reveals that binding of Cripto to the TGFbeta ligand Activin B can block Activin B-mediated suppression of cell proliferation. Furthermore, this study also demonstrates that antibody blockade of Cripto function may prove useful in the inhibition of tumorigenesis. Cripto was first discovered 15 years ago and was suitably named for its...
Source: Biotech Week (2003-09-10)
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